Hypothesis: Initiated re-evolution of a mutated DNA in bone-marrow cells yields change in neural cells

"The interaction of NSCs with transplanted BMSCs and whether the interaction is beneficial to the treatment remains to be determined. Confirming these may aid in improving the understanding of the potential of cell therapy and improving the efficacy." 

"The biochemical basis of cell differentiation is the synthesis by the cell of a particular set of proteins, carbohydrates, and lipids. This synthesis is catalyzed by proteins called enzymes. Each enzyme in turn is synthesized in accordance with a particular gene, or sequence of nucleotides in the DNA of the cell nucleus. A particular state of differentiation, then, corresponds to the set of genes that is expressed and the level to which it is expressed."

cited from

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360510/


NSC and BMSC are neural and bone marrow stem cells. The interaction between neural and bone marrow stem cells might be unknown, but if you change the code of one of them, it should be clear, that the interaction results in a reprogrammed cell structure and DNA replication is renewed. The result should be a natural reprogrammed state of the neural cell.

Careful studies should reveal the desired result.


That means if the problematic DNA failure, that is assigned by the specific disease, is isolated, researchers should be able to resolve any problem associated with the disease.

The following genes have been identified as crucial in this issue:

"Mutations in the leucine-rich repeat kinase 2 (LRRK2) are the most common, known cause of autosomal dominant PD.8, 9 The LRRK2 gene has 51 exons, encoding a very large protein, termed lrrk2 (or dardarin), which contains two predicted enzymatic domains (GTPase and kinase) and multiple protein-protein interaction domains.10

Many novel variants have been identified in this large gene in PD patients, but only six of these (Asn1437His, Arg1441Cys, Arg1441Gly, Tyr1699Cys, Gly2019Ser, and Ile2020Thr) can be considered as definitely disease-causing, on the basis of co-segregation with disease in families, and absence in controls.10, 11 In studies on large referral series, the LRRK2 mutations explain for up to ~10% of the patients with familial PD and a clear autosomal dominant pattern of inheritance.12 Among these mutations, Gly2019Ser is by far the most common (see below); 13, 14 Arg1441Cys is the second most frequent mutation, detected in several populations.15 Another variant targeting the same codon, Arg1441Gly, is a frequent founder mutation among PD patients from the Basque population, but rare elsewhere.16 Asn1437His, Tyr1699Cys, and Ile2020Thr have been found rarely."

Cite by:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578399/

For example in the case of Asn1437His people have identified the crucial effected mutation locations and the effected protein, see here:

https://www.ncbi.nlm.nih.gov/clinvar/variation/39183/

Now, what I don't understand and never will be able to understand and what will mention and note and insist on until it is common practice is the fact, that the measurement of the pH of blood is the most important thing to be considered, since the pH of blood defines the health of the body. It must be alkalic! I don't care about all that other stuff that is usually measured, since this all depends on the pH of blood.

This is so easy to see but people are blind. If your pH of blood is alkalic everything is okay. The more alkalic it is the better your health. That is so obvious, but people only measure if they did the pH of urine. Who cares about this? Not me at least.

So, if the pH of blood is in the alkalic range everything should be fine. Problems occur, when this not the case. And if is going to be acidity then your body gets serious problems and if it is gets too low, you eventually die.